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Kinase-dead PKB gene therapy coined with hyperthermia

18/12/2003· Hyperthermia (HT) is an experimental cancer treatment modality, which, in coination with ionizing radiation therapy (RT), achieves superior local control over that observed with RT alone for

Modulated Electrohyperthermia: A New Hope for Cancer Patients

According to the World Health Organization, the prevalence of cancer has increased worldwide. Oncological hyperthermia is a group of methods that overheat the malignant tissues locally or systematically. Nevertheless, hyperthermia is not widely accepted, primarily because of the lack of selectivity for cancer cells and because the temperature-triggered higher blood flow …

Melatonin potentiates "inside-out" nano-thermotherapy in

NP-based hyperthermia, or termed as nano-thermotherapy, is highly expected to have great potential for the revolutionalization of current hyperthermia methods. 34 Heat can be generated through the NPs infused within the tumor issue by absorbing the energy from an external source and thus realize the so-called “inside-out” hyperthermia, in a way to induce selective heating …

10.34172/apb.2022.060 Manuscript

nanoparticles in nanofibers provide the possibility of hyperthermia in the area where fibers present. Fe. 3. O. 4. nanoparticles generate heat more evenly under AMF which can overcome hyperthermia challenges. Therefore, these nanofibers can be utilized as post-surgical implants for various cancer treatments such as liver or colorectal cancer in

Synthesis and appliion of magnetite dextran-spermine

17/6/2017· An adequate amount of heat should be delivered to the tumor so that it reaches the desired temperatures, or it may induce resistance. The magnetic fluid hyperthermia is a non-invasive method which can deliver the desired heat to deep-seated tumors without damaging healthy tissues.

(PDF) The Oncotherm story in person view (History of

"Internal" hyperthermia is a type of thermotherapy by which heat is sup­ plied to tumor tissue in situ. There are three different techniques for pro­ viding internal hyperthermia: (1

Assessing hyperthermia performance of hybrid textile

The precise control of the physiochemical properties of these magnetic systems is crucial for hyperthermia appliions, as the induced heat is highly dependent on these properties.

Hyperthermia and chemotherapy using Fe(Salen

20/2/2017· We previously reported that μ-oxo N,N’-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a magnetic organic compound, has direct anti-tumor activity, and generates heat in …

Stem cell-based gene therapy activated using magnetic

17/3/2020· Mild Magnetic Hyperthermia-Activated Stem Cell-Based Gene Therapy. A) MCNPs composed of a ZnFe 2 O 4 magnetic nanoparticle (MNP) core and a mesoporous silica (mSi) shell (i) are functionalized with polyethyleneimine (PEI) to allow for complexing with a heat-inducible therapeutic plasmid (iii). The MCNPs enhance delivery of the heat-inducible plasmid into the …

Practical bioinstrumentation developments for AC magnetic

19/2/2019· In addition, these are expensive, delie (silicone tube), and the probability of cross contamination is high. This is one of the reasons for the limited nuer of experiments using real-time temperature measurements in magnetic fluid hyperthermia research involving cell cultures; such experiments require a contamination-free environment [ 8 , 9 , 10 ].

Potential enhancement of host immunity and anti-tumor

29/6/2020· Modulated electro-hyperthermia (mEHT) is a form of hyperthermia used in cancer treatment. mEHT has demonstrated the ability to activate host immunity by inducing the release of heat shock proteins, triggering apoptosis, and destroying the integrity of cell meranes to enhance cellular uptake of chemo-drugs in tumor cells. Both curcumin and resveratrol are …

Hyperthermia Improves Solubility of Intravesical

Generally, heat improves drug solubility, and consequently some of the improved drug delivery that is shown with bladder hyperthermia might be due to improved drug solubility . Optimized administration regimens of intravesical gemcitabine without hyperthermia exist, but there is a lack of data on the solubility of gemcitabine when heated [ 17 ].

Enhancing Magnetic Hyperthermia Nanoparticle Heating

29/11/2021· One of the most interesting approaches is hyperthermia, which is a non-invasive technique to selectively kill target cancer cells by raising the microenvironment tumor temperature to 43 °C to 45 °C, resulting in cell apoptosis due to the irreversible cell damage caused by their low heat resistance, where on the other hand, normal cell damage is minimum …

Magnetic hyperthermia enhances cell toxicity with respect

1/1/2017· Magnetic hyperthermia is a new type of cancer treatment designed for overcoming resistance to chemotherapy during the treatment of solid, inaccessible human tumors. The main challenge of this technology is increasing the local tumoral temperature with minimal side effects on the surrounding healthy tissue.

Owner’s Manual & Installation Guide APRIL 2014

Hyperthermia occurs when the internal temperature of the body reaches a level several degrees above the normal body temperature of 98.6º F. The symptoms of hyperthermia include an increase in the internal temperature of the body, dizziness, lethargy, drowsiness and fainting. The effects of Hyperthermia include: 1. Failure to perceive heat 2.

Hyperthermia versus Oncothermia: Cellular Effects in

14/4/2013· Hyperthermia means overheating of the living object completely or partly. Hyperthermia, the procedure of raising the temperature of a part of or the whole body above normal for a defined period of time, is applied alone or as an adjunctive with various established cancer treatment modalities such as radiotherapy and chemotherapy. However, hyperthermia …

Cancers | Free Full-Text | Hyperthermia: The Optimal

9/1/2019· These approaches involve improving oxygen availability, radio-sensitizing or killing the hypoxic cells, or utilizing high LET (linear energy transfer) radiation leading to a lower OER (oxygen enhancement ratio). Interestingly, hyperthermia (heat treatments of 39–45 °C) induces many of these effects.

Synergic antitumor effect of SKLB1002 and local

21/12/2012· In addition, hyperthermia exhibits a direct cell-killing effect at temperatures ranging from 42 to 45 °C. But the sure mechanism is not clear up to now. The present study suggests that the coination therapy of hyperthermia with antiangiogenesis drugs can …

Nanoparticle-mediated hyperthermia in cancer therapy

1/8/2011· Clinical rationale & biological basis for hyperthermia. Hyperthermia has a long history in the annals of cancer management. A correlation between erysipelas (a streptococcal skin infection) and tumor regression had been observed for over a century before William Coley first documented evidence of a relationship between infection and cancer regression in sarcoma …

Enhanced Tumor Synergistic Therapy by Injectable Magnetic

enhance the therapeutic effect of hyperthermia. This single magnetic nanoparticle exerts dual functions of hyperthermia and alytic therapy to synergistically treat tumors, overcoming the resistance of tumor cells to induced thermal stress without causing severe side effects to normal tissues at 42 °C hyperthermia.

Fever In the Intensive Care Patient - StatPearls - NCBI

31/3/2021· Also, the ACCCM and IDSA recommend that fever in ICU should be investigated only if the temperature is ≥101 degrees F. Hyperpyrexia or hyperthermia is defined as a temperature of more than 105.8 degrees F (or 41 degrees C) and is uncommonly encountered in …

Magnetic hyperthermia with magnetite nanoparticles

15/7/2016· In series with the original coils of the heater, we connected a 40 turn coil, 40 mm in diameter and 65 mm in length. The copper wire section was 1.7 mm 2, and the total measured resistance of the coil was 0.038 Ω with inductance 23 μH (HP4284A impedance meter, Hewlett-Packard, USA). The unmodified heater had a resistance of 0.646 Ω and an inductance of 105.4 …

The Impact of Dehydration and Hyperthermia on Circulatory

Background: Reduced glutathione (GSH) is one of the main thiols involved in antioxidant defense. Changes in circulatory levels of GSH during exercise are associated with hyperthermia and dehydration. The mechanisms by which these alterations occur are not entirely known. We hypothesize that erythrocytes could be an important source of circulatory GSH during heat …

Troubleshooting Manual AquaLink RS OneTouch Control Systems

Prolonged immersion in hot water may induce hyperthermia. Hyperthermia occurs when the internal temperature of the body reaches a level several degrees above the normal body temperature of 98.6° F. The symptoms of hyperthermia include dizziness, fainting, drowsiness, lethargy, and an increase in the internal temperature of the body.

Hyperthermia in coined treatment of cancer - ScienceDirect

1/8/2002· The rationale is based on a direct cell-killing effect at temperatures above 41–42°C. 1 However, the thermal dose–response relation varies among cell lines and depends, furthermore, on microenvironmental factors such as pH. 2 After a heat shock, all cell types show increased thermoresistance for 24–48h (thermotolerance). The required temperatures derived from the …

Cellular mechanisms of neuronal damage from hyperthermia

1/1/2007· Introduction. Hyperthermia can produce or contribute to neuronal injury under multiple environmental and clinical conditions. Recently hyperthermia has received attention due to high profile incidents involving athletes, amphetamine use, soldiers in hot environments, and the increased incidence of severe heat waves.

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